Biography
Dr. Alexander Y. Lin is a plastic surgeon who specializes in craniofacial and maxillofacial surgery (operations on the skull, face and jaw), as well as plastic surgery for pediatric conditions. He is director of surgical innovations for UCSF's plastic surgery division. He is also co-director of the UCSF Craniofacial Center and co-director of the UCSF Center for Advanced 3D+ Technologies, serving as the Oakland site director for both.
Lin's mission in medicine – guiding his practice, research and innovations – is to improve the lives of children and their families. In patient care, he focuses on what, he believes, makes us human: our faces, speech (palate) and hands. Specifically, he provides care for patients with cleft lip, cleft nose and cleft palate or other conditions of facial structures. He also performs surgery to correct problems with the bones of the skull and face (due to disorders such as craniosynostosis), the jaw (which can cause poor teeth alignment and breathing problems), and the orbit (eye socket).
In his translational research, Lin focuses on 3D printing and advanced visualization technologies to allow the use of sterile models and improve surgery by facilitating smaller incisions – serving to make procedures faster and more accurate. He has funded grants to develop artificial intelligence applications for detecting speech problems earlier in children's development, which can enable kids to receive speech therapy or corrective surgery sooner. He also studies how to merge scaffolding (implantable materials that support tissue growth) with biologic tissues for complex reconstruction surgeries.
After earning his bachelor's and master's degrees at Stanford University, Lin earned his medical degree at the Johns Hopkins University School of Medicine. He completed a residency in general surgery and plastic and reconstructive surgery at UCSF, which included a two-year research fellowship in vascular immunobiology at Massachusetts General Hospital. He completed a fellowship in craniofacial, maxillofacial and pediatric plastic surgery at Children's Hospital of Pittsburgh. He also earned a master of business administration degree, with a focus on innovation, from Washington University in St. Louis.
Prior to joining UCSF, Lin served as chief of plastic surgery at St. Louis University School of Medicine. There, he held the Alan A. and Edith L. Wolff Endowed Chair in Craniofacial, Maxillofacial and Pediatric Plastic Surgery and co-founded and co-directed the 3D Printing Center of Excellence at SSM Health Cardinal Glennon Children's Hospital, where he also directed the St. Louis Cleft-Craniofacial Center.
Nationally, Lin provides leadership in three key roles, serving on the American Society of Maxillofacial Surgeons' executive board, as vice chair of the craniomaxillofacial section of the American Society of Plastic Surgeons' exam committee, and as chair of the clinical study section of the Plastic Surgery Foundation (which supports impactful research through its grants program).
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Olin Business School, Washington University | MBA | Master of Business Administration | 12/2020 |
Children’s Hospital of Pittsburgh (CHP), University of Pittsburgh Medical Center (UPMC) | Fellowship: Craniofacial, Maxillofacial, and Pediatric Plastic Surgery | 06/2010 | |
University of California San Francisco (UCSF) | Residency: General Surgery and Plastic & Reconstructive Surgery | 06/2009 | |
Massachusetts General Hospital (MGH), Harvard Medical School | Research Fellowship: Vascular Immunobiology | 06/2007 | |
University of California San Francisco (UCSF) | Internship: General Surgery and Plastic & Reconstructive Surgery | 06/2003 | |
Johns Hopkins University School of Medicine | MD | Medical School: M.D. with Alpha Omega Alpha (AOA) honors | 05/2002 |
Stanford University | MS | Graduate: Master of Science, M.S. in Statistics | 06/1996 |
Stanford University | BA | Undergraduate: Bachelor of Arts, A.B. in Psychology with Distinction | 06/1996 |
Publications
- The impact of medications on salivary flow and oral health-related quality of life in postradiation head and neck cancer patients: results of the OraRad study.| |
PubMed
- Tumor-intrinsic and immune-related features associated with treatment failure in human papillomavirus-related oropharyngeal cancer.| |
PubMed
- Cost-effective urine recycling enabled by a synthetic osteoyeast platform for production of hydroxyapatite.| |
PubMed
- In-House 3D Printing for Craniofacial Trauma: 7-Year Review.| |
PubMed
- Neurometabolic network (NMetNet) for functional neurological disorder in children and adolescents.| |
PubMed
- International Expert-Based Consensus Definition, Classification Criteria, and Minimum Data Elements for Osteoradionecrosis of the Jaw: An Interdisciplinary Modified Delphi Study.| |
PubMed
- Chronic inflammation and vascular cell plasticity in atherosclerosis.| |
PubMed
- Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability.| |
PubMed
- ChatGPT for improving postoperative instructions in multiple fields of plastic surgery.| |
PubMed
- Females have lower salivary flow than males, before and after radiation therapy for head/neck cancer.| |
PubMed
- Radiation Therapy for HPV-Positive Oropharyngeal Squamous Cell Carcinoma: An ASTRO Clinical Practice Guideline.| |
PubMed
- A Prospective Phase I/II Clinical Trial of High-Dose Proton Therapy for Chordomas and Chondrosarcomas.| |
PubMed
- Reduced mouth opening in patients with head and neck cancer treated with radiation therapy: an analysis of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad).| |
PubMed
- Surgical Management in Isolated Squamosal Craniosynostosis: A Systematic Review.| |
PubMed
- The Role of Postoperative Nasal Stents in Cleft Rhinoplasty: A Systematic Review.| |
PubMed
- Seeing Cleft Lip from a New Angle: Crowdsourcing to Determine whether Scar Severity or Lip Angle Matters More to the General Public.| |
PubMed
- Oral health-related quality of life after radiation therapy for head and neck cancer: the OraRad study.| |
PubMed
- Close Margins After Transoral Robotic Surgery for Human Papillomavirus-Positive Oropharyngeal Carcinoma: A Review of the Literature and Practical Recommendations.| |
PubMed
- Acute toxicity in patients treated with concurrent chemoradiotherapy with proton versus intensity-modulated radiation therapy for nonmetastatic head and neck cancers.| |
PubMed
- Defining Ideal External Female Genital Anatomy via Crowdsourcing Analysis.| |
PubMed
- Radiation therapy for head and neck cancer leads to gingival recession associated with dental caries.| |
PubMed
- Tooth Failure Post-Radiotherapy in Head and Neck Cancer: Primary Report of the Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (OraRad) Study.| |
PubMed
- Exposed bone in patients with head and neck cancer treated with radiation therapy: An analysis of the Observational Study of Dental Outcomes in Head and Neck Cancer Patients (OraRad).| |
PubMed
- Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units.| |
PubMed
- Work Outcomes after Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for Oropharyngeal Cancer.| |
PubMed
- Adverse events of after-loading high dose rate brachytherapy reported to the United States Food and Drug Administration (FDA).| |
PubMed
- The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group.| |
PubMed
- Minimum Reporting Standards for in vivo Magnetic Resonance Spectroscopy (MRSinMRS): Experts' consensus recommendations.| |
PubMed
- A magnetic resonance spectroscopy investigation in symptomatic former NFL players.| |
PubMed
- Epidemiologic factors in patients with advanced head and neck cancer treated with radiation therapy.| |
PubMed
- Three-dimensional printing in medicine: a systematic review of pediatric applications.| |
PubMed
- Plastic Surgery Innovation with 3D Printing for Craniomaxillofacial Operations.| |
PubMed
- A prospective clinical trial of proton therapy for chordoma and chondrosarcoma: Feasibility assessment.| |
PubMed
- Preparing for the Plastic Surgery In-Service Exam: Evidence-Based Essentials for the Plastic Surgery Resident.| |
PubMed
- Validation and application of a fast Monte Carlo algorithm for assessing the clinical impact of approximations in analytical dose calculations for pencil beam scanning proton therapy.| |
PubMed
- Tissue Engineering Scaffolds Fabricated in Dissolvable 3D-Printed Molds for Patient-Specific Craniofacial Bone Regeneration.| |
PubMed
- Systematic Review: Online Crowdsourcing to Assess Perceptual Speech Outcomes.| |
PubMed
- Demystifying the "Triple Point: " Technical Nuances of the Fronto-Orbital Advancement.| |
PubMed
- Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation.| |
PubMed
- Temporomandibular Joint Septic Arthritis.| |
PubMed
- Squamosal Craniosynostosis: Defining the Phenotype and Indications for Surgical Management.| |
PubMed
- Cryogel scaffolds from patient-specific 3D-printed molds for personalized tissue-engineered bone regeneration in pediatric cleft-craniofacial defects.| |
PubMed
- Military Blast Injury and Chronic Neurodegeneration: Research Presentations from the 2015 International State-of-the-Science Meeting.| |
PubMed
- A New Classification of Three-Dimensional Printing Technologies: Systematic Review of Three-Dimensional Printing for Patient-Specific Craniomaxillofacial Surgery.| |
PubMed
- The Plastic Surgery Match: A Quantitative Analysis of Applicant Impressions From the Interview Visit.| |
PubMed
- Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging.| |
PubMed
- Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy.| |
PubMed
- Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning.| |
PubMed
- Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly.| |
PubMed
- Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for the Management of Patients With Positional Plagiocephaly: Executive Summary.| |
PubMed
- Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Diagnosis of Patients With Positional Plagiocephaly: The Role of Imaging.| |
PubMed
- Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline for the Management of Patients With Positional Plagiocephaly: The Role of Physical Therapy.| |
PubMed
- Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Management of Patients With Positional Plagiocephaly: The Role of Repositioning.| |
PubMed
- Guidelines: Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on the Role of Cranial Molding Orthosis (Helmet) Therapy for Patients With Positional Plagiocephaly.| |
PubMed
- Improved Temporomandibular Joint Position After 3-Dimensional Planned Mandibular Reconstruction.| |
PubMed
- Cavum Septi Pellucidi in Symptomatic Former Professional Football Players.| |
PubMed
- Development of Volunteer International Craniofacial Surgery Missions: The Komedyplast Protocol.| |
PubMed
- Custom porous polyethylene implants for large-scale pediatric skull reconstruction: early outcomes.| |
PubMed
- Rhinoplasty sizers.| |
PubMed
- Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.| |
PubMed
- BMP-2-mediated regeneration of large-scale cranial defects in the canine: an examination of different carriers.| |
PubMed
- Acellular dermal matrix in the treatment and prevention of exposed vertical expandable prosthetic titanium ribs.| |
PubMed
- Nasal strips for evaluating and classifying valvular nasal obstruction.| |
PubMed
- A predictive test and classification for valvular nasal obstruction using nasal strips.| |
PubMed
- Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation.| |
PubMed
- Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.| |
PubMed
- Inhibited aortic aneurysm formation in BLT1-deficient mice.| |
PubMed
- Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells.| |
PubMed