Biography
Kratz worked as research fellow in the Thoracic Oncology Lab from 2008-2011 where he played a pivotal role in the development of a prognostic assay for early-stage lung cancer patients. The novel assay was validated in an international clinical trial led by thoracic surgeons David M. Jablons, M.D. and Michael Mann, M.D. The assay better predicted risk of death in early-stage lung cancer patients versus conventional staging guidelines and later successfully identified Stage 1A lung cancer patients who had a very high likelihood of mortality after surgery. Kratz finished his clinical training as a clinical fellow in Thoracic Surgery at UCSF from 2014 - 2017 and subsequently joined the faculty.
Kratz holds the Van Auken Endowed Chair in Thoracic Oncology. He has been the recipient of numerous awards and honors including the UCSF Health Exceptional Physician Award, Hellman Family Clinical-Translational Research Development Award, Michael DeBakey Research Scholarship, Cardiothoracic Surgery Faculty Teaching Award, Haile T. Debas Academy of Medical Educators Excellence in Teaching Award, Partners Healthcare Teaching Award, Willard M. Daggett Award, Edward Churchill Surgical Research Fellowship, Wyeth Scholarship of the American College of Surgeons, John E. Thayer Scholarship Award, Howard Hughes Medical Fellows Program Continued Support Award, and designation as a Soma Weiss Scholar.
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Haile T. Debas Academy of Medical Educators Excellence in Teaching Award | University of California, San Francisco | 2023 |
Cardiothoracic Surgery Faculty Teaching Award | University of California, San Francisco | 2021 |
Michael DeBakey Research Scholarship | American Association for Thoracic Surgery | 2019 |
Hellman Family Clinical-Translational Research Development Award | Bakar ImmunoX Initiative | 2019 |
Haile T. Debas Academy of Medical Educators Excellence in Teaching Award | University of California, San Francisco | 2019 |
Van Auken Endowed Chair in Thoracic Oncology | University of California, San Francisco | 2018 |
UCSF Health Exceptional Physician Award | University of California, San Francisco | 2017 |
First Place, Oral Presentation, Harvard Medical School Surgery Research Conference | Harvard Medical School | 2012 |
Partners HealthCare Resident/Fellow as Teacher Award | Partners HealthCare | 2012 |
President's Conference Selection, World Conference on Lung Cancer | International Association for the Study of Lung Cancer | 2011 |
Willard M. Daggett Award | Massachusetts General Hospital | 2010 |
Wyeth Scholarship of the American College of Surgeons for the Study of Inflammation | Massachusetts General Hospital | 2008 |
Aesculapian Club | Harvard Medical School | 2006 |
John E. Thayer Scholarship Award | Harvard Medical School | 2006 |
Soma Weiss Scholar Award | Harvard Medical School | 2005 |
Howard Hughes Research Training Fellowship | Harvard Medical School | 2004 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California | Fellowship | Cardiothoracic Surgery | 2017 |
Massachusetts General Hospital | Residency | General Surgery | 2014 |
Harvard Medical School | M.D. (Magna Cum Laude) | 2006 | |
Stanford University | M.A. | Philosophy | 2000 |
Stanford University | B.S. (with Honors with Distinction) | Biological Sciences | 1999 |
Stanford University | B.A. (with Distinction) | Philosophy | 1999 |
Board Certifications
American Board of Surgery
American Board of Thoracic Surgery
Clinical Expertise
Carcinoid Tumors
Chest Wall Tumors
Lung Transplantation
Malignant Mesothelioma
Mediastinal Masses
Minimally Invasive Thoracic Surgery
Non-Small Cell Lung Cancer
Robotic Thoracic Surgery
Small Cell Lung Cancer
Thymoma & Thymic Carcinoma
Tracheal Tumors
Video-Assisted Thoracoscopic Surgery (VATS)
Clinical Trials
- Related Conditions: Postoperative Pain, Opioid Use| Start Date: | End Date:
In the News
Grants and Funding
- Immune Phenotypes of High-Risk Early Stage Lung Adenocarcinoma | American Association of Thoracic Surgery | 2020-07-01 - 2022-06-30 | Role: Principal Investigator
- CoProject Pilot in Early-Stage Lung Cancer | Bakar ImmunoX Foundation | 2019-08-01 - 2021-07-31 | Role: Principal Investigator
- COVID-19 Related Rapid Research Pilot Initiative | University of California, San Francisco | 2020-06-03 - 2021-06-02 | Role: Principal Investigator
- Lung Cancer Tumor Immune Microenvironments | Helen Diller Family Comprehensive Cancer Center | 2019-10-19 - 2020-09-30 | Role: Principal Investigator
Research Narrative
The Kratz lab focuses on the genetic and immunological mechanisms that drive early-stage, surgically resectable thoracic malignancies. These malignancies include lung cancer, esophageal cancer, and thymic cancer. The lab uses novel high-throughput “-omics” techniques such as genomic DNA and RNA sequencing, proteomics, and metabolomics to unravel the complex nature of early-stage thoracic malignancies. At the same time, the lab actively investigates the complex immunological landscapes that nurture the growth of these malignancies. The knowledge gained from these investigations is being used to identify novel therapeutic targets and therapies for patients with early-stage, yet deadly thoracic malignancies.
Research Interests
Molecularly-targeted cancer therapies
Prognostic assays for early stage lung cancer
Inflammation in lung tumorigenesis
Publications
- Precision medicine-based platform to guide the treatment of EML4-ALK driven lung cancers and other NSCLC in real time.| | UCSF Research Profile
- Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study.| | PubMed
- A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts.| | PubMed
- Trans-Sternal Multilevel Corpectomy for Cervicothoracic Renal Cell Metastasis: 2-Dimensional Operative Video.| | PubMed
- Quantitative Polymerase Chain Reaction and Precision Medicine.| | UCSF Research Profile
- Treatments for dengue: a Global Dengue Alliance to address unmet needs.| | PubMed
- PET Standardized Uptake Value May Influence Surgical Planning for Clinical Stage IA Non-Small Cell Lung Cancer.| | PubMed
- Phase II trial of neoadjuvant osimertinib for surgically resectable EGFR -mutated non-small cell lung cancer.| | UCSF Research Profile
- Transcriptional space-time mapping identifies concerted immune and stromal cell patterns and gene programs in wound healing and cancer.| | PubMed
- 287 Genomic and Immunologic Characterization of Lung Adenocarcinoma in Never Smokers vs. Smokers.| | UCSF Research Profile
- Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas.| | PubMed
- SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.| | PubMed
- Outcomes of gynecologic cancer surgery during the COVID-19 pandemic: an international, multicenter, prospective CovidSurg-Gynecologic Oncology Cancer study.| | PubMed
- Discovering dominant tumor immune archetypes in a pan-cancer census.| | PubMed
- Genetic and immunologic features of recurrent stage I lung adenocarcinoma.| | PubMed
- Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.| | PubMed
- Perioperative Lung Resection Outcomes After Implementation of a Multidisciplinary, Evidence-based Thoracic ERAS Program.| | PubMed
- Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease.| | UCSF Research Profile
- Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study.| | PubMed
- P26.02 A Phase II Trial of Neoadjuvant Osimertinib for Surgically Resectable EGFR-Mutant Non-Small Cell Lung Cancer: Updated Results.| | UCSF Research Profile
- SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.| | PubMed
- Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay.| | PubMed
- SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.| | PubMed
- Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early-Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit From Adjuvant Chemotherapy.| | PubMed
- SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator.| | PubMed
- Resectability, Recurrence, and Risk Stratification of Giant Solitary Fibrous Tumors in the Thoracic Cavity.| | PubMed
- Timing of surgery following SARS-CoV-2 infection: an international prospective cohort study.| | PubMed
- Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models.| | PubMed
- Commentary: Cardiothoracic surgery training: Global challenges without universal solutions.| | PubMed
- MO01.13 Molecular Risk Stratification is Independent of EGFR Mutation Status in Identifying Early Stage Non-Squamous Non-Small Cell Lung Cancer Patients at Risk for Recurrence and Likely to Benefit from Adjuvant Chemotherapy.| | UCSF Research Profile
- Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.| | PubMed
- Delaying surgery for patients with a previous SARS-CoV-2 infection.| | PubMed
- Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.| | PubMed
- Pulmonary Embolus of Benign Liver Tissue Following Partial Hepatectomy.| | UCSF Research Profile
- Comparison of Conventional TNM and Novel TNMB Staging Systems for Non-Small Cell Lung Cancer.| | PubMed
- Esophagectomy Outcomes after Implementation of an Enhanced Recovery after Surgery Program.| | UCSF Research Profile
- MA06.09 Timing of Driver Mutation Development and the Genetic Evolution of Semi-Solid Lung Nodules into Early NSCLC.| | UCSF Research Profile
- P1.14-58 A Phase II Study to Evaluate Neoadjuvant Osimertinib for Surgically Resectable, EGFR-Mutant Non-Small Cell Lung Cancer.| | UCSF Research Profile
- Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma.| | PubMed
- Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging.| | PubMed
- Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine Development.| | PubMed
- Quantitative Polymerase Chain Reaction for Companion Diagnostics and Precision Medicine Application.| | UCSF Research Profile
- Central Airway Obstruction Due to Tracheal Glomus Tumor.| | PubMed
- Giant right coronary artery aneurysm presenting as cardiac tamponade.| | PubMed
- P2.16-12 Expanded Data Confirm Molecular Testing Identifies Lung Adenocarcinoma Patients, Including Stage IA, Who Benefit from Adjuvant Chemotherapy.| | UCSF Research Profile
- P3.03-24 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer Staging.| | UCSF Research Profile
- Propensity Matched Analysis of Perioperative Outcomes in Robotic-Assisted Thoracic Surgery, Video Assisted Thoracic Surgery, and Open Lung Resections.| | UCSF Research Profile
- Intraoperative identification and treatment of a giant right coronary artery aneurysm.| | PubMed
- Surgical Management of Pulmonary Mucormycosis in Third-Trimester Pregnancy.| | PubMed
- Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer.| | PubMed
- Management of Lung Cancer Invading the Superior Sulcus.| | PubMed
- OA19.06 Adjuvant Chemotherapy Decisions Based on Molecular Risk Status Improves Outcomes in Early Stage, Non-Small Cell Lung Cancer.| | UCSF Research Profile
- P1.03-066 Incorporation of a Molecular Prognostic Classifier Improves Conventional Non-Small Cell Lung Cancer TNM Staging Topic: Staging.| | UCSF Research Profile
- High risk, high reward: An analysis of outcomes for candidates awaiting hepatic re-transplantation.| | PubMed
- High risk, high reward: An analysis of outcomes for candidates awaiting hepatic re-transplantation.| | PubMed
- Wnt7A is a putative prognostic and chemosensitivity marker in human malignant pleural mesothelioma.| | PubMed
- The race to liver transplantation: a comparison of patients with and without hepatocellular carcinoma from listing to post-transplantation.| | PubMed
- Prognostic and Predictive Biomarker Signatures.| | UCSF Research Profile
- The migrated liver transplantation candidate: insight into geographic disparities in liver distribution.| | PubMed
- Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer.| | PubMed
- International trial of adjuvant therapy in high risk stage I non-squamous cell carcinoma identified by a 14-gene prognostic signature.| | PubMed
- Prognostic assay in small, node-negative non-small cell lung cancer--reply.| | PubMed
- The role of stem cells in airway repair: implications for the origins of lung cancer.| | PubMed
- A prognostic assay to identify patients at high risk of mortality despite small, node-negative lung tumors.| | PubMed
- Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.| | PubMed
- A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies.| | PubMed
- IL11 is prognostic of survival in lung adenocarcinoma.| | UCSF Research Profile
- Child neurology: Brachial plexus birth injury: what every neurologist needs to know.| | PubMed
- Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.| | PubMed
- Cancer stem cells in lung tumorigenesis.| | PubMed
- Genomic prognostic models in early-stage lung cancer.| | PubMed
- Anal canal duplication associated with presacral cyst.| | PubMed
- Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.| | PubMed
- Fluid Mechanical Forces as Extrinsic Modifiers of Endothelial Function.| | UCSF Research Profile
- Clinical pulmonary autograft valves: pathologic evidence of adaptive remodeling in the aortic site.| | PubMed
- Catalysis of peptide dissociation from class II MHC-peptide complexes.| | PubMed