Cell Article Discusses The Role of Matrix Crosslinking in Tumor Progression by Enhancing Integrin Signaling

Weaver and colleagues showed that collagen crosslinking drives tumor progression. The report established a correlation between collagen crosslinking and extracellular matrix (ECM) stiffness in mouse models and implicates the ECM-crosslinking enzyme lysyl oxidase (LOX) as a culprit driving stiffness-associated tumor progression.

This article has been highlighted in the journals Cancer Cell and in Nature.