Biography
Dr. Hobart W. Harris is an expert in treating surgical infections, diseases of the pancreas and biliary system and abdominal wall hernias, including pancreas, gallbladder and bile duct cancer, acute and chronic pancreatitis, islet autotransplantation for chronic pancreatitis, complex gallstone disease, intra-abdominal sepsis, serious infections of the skin and soft tissue, and enterocutaneous fistulas. He treats patients with complicated and often life-threatening conditions through the Complex Abdominal Surgery Program. Dr. Harris is also a pioneer and leader in the management and repair of complex ventral (incisional) hernias. Specifically, he is an expert at repairing gigantic ventral hernias, where closure of the defect and reconstructing the abdominal wall requires advanced techniques, such as progressive pneumoperiteum whereby the abdominal wall muscles are first stretched prior to repairing the hernia.
Dr. Harris earned his undergraduate, medical and public health degrees at Harvard University, before completing an internship and residency in general surgery at UCSF. After residency training, he completed a fellowship in Hepatobiliary Surgery at the University of Hong Kong, Queen Mary Hospital before joining the faculty at UCSF in 1994. Harris is a Fellow of the American College of Surgeons and is a member of numerous surgical and scientific societies including the American Surgical Association.
Videos
Education
| Institution | Degree | Dept or School | End Date | 
|---|---|---|---|
| Harvard University | M.D. | School of Medicine | 1983 | 
| University of California, San Francisco | Residency | School of Medicine - Surgery | 
Board Certifications
- American Board of Surgery, 1994
Clinical Expertise
Acute Pancreatitis
Bile Duct Injuries
Chronic Pancreatitis
Gall Bladder Disease
Ventral (Incisional) Hernia
Complex Abdominal Surgery
Recurrent Hernia
Laparoscopic Inguinal Hernia Repair
Gastrointestinal Cancer
Gastrointestinal Surgery
Intra-abdominal Sepsis
Pancreas Surgery
Pancreatic Cancer
Soft Tissue Infections
Enterocutaneous Fistula
Hepatobiliary Surgery
Clinical Trials
- Related Conditions: Laparotomy, Hernia| Start Date: | End Date:
- A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery (NCT02584153)Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
- Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
In the News
Grants and Funding
- Research Training in Gastrointestinal Surgery | NIH | 1988-07-01 - 2021-06-30 | Role: Principal Investigator
- Complex Ventral Hernia Repair | NIH | 2013-07-15 - 2017-06-30 | Role: Principal Investigator
- Lipoproteins and Microbial Immunity | NIH | 2010-08-15 - 2015-07-31 | Role: Principal Investigator
- Lipoproteins Modulate the Hepatic Response to Endotoxin | NIH | 1999-05-01 - 2010-01-31 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-10-01 - 2007-11-30 | Role: Co-Investigator
- CHYLOMICRON REMNANTS &ATHEROSCLEROSIS | NIH | 1988-11-05 - 1900-01-01 | Role: Principal Investigator
Research Narrative
Dr. Harris is Director of the Infection, Injury and Immunity Lab. His research focuses on surgical infections, innate immunity and the management of complex ventral hernias. He is also an innovator, inventor and entrepreneur in the surgical field.
Research Pathways
Publications
- Layilin regulates Treg motility and suppressive capacity in skin.| | PubMed PubMed
- Ventral hernia repair with T-line hernia mesh: A multi-institutional experience.| | PubMed PubMed
- Expert consensus for key components of a high-quality ventral hernia repair operative note.| | PubMed PubMed
- The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa.| | PubMed PubMed
- Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.| | PubMed PubMed
- Quality of life measures and cost analysis of biologic versus synthetic mesh for ventral hernia repair: The Preventing Recurrence in Clean and Contaminated Hernias randomized clinical trial.| | PubMed PubMed
- Data Requirement for Animal-Derived Wound Care Devices: Limitations of the 510(k) Regulatory Pathway.| | PubMed PubMed
- Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries.| | PubMed PubMed
- A Novel Polypropylene Mesh (T-Line®) for Abdominal Wall Repair: Early Experience at Three Centers in the United States.| | PubMed PubMed
- Biologic Versus Synthetic Mesh in Ventral Hernia Repair: Participant-Level Analysis of Two Randomized Controlled Trials at Twenty-Four to Thirty-Six Months.| | PubMed PubMed
- Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.| | PubMed PubMed
- Expert Consensus for Key Features of Operative Reports of Ventral Hernia.| | PubMed PubMed
- Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies.| | PubMed PubMed
- Innovations for Incisional Hernia Prevention.| | PubMed PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | PubMed PubMed
- Cost-Effectiveness Analysis of Inguinal Hernia Repair With Mesh Performed by Surgeons and Medical Doctors in Ghana.| | PubMed PubMed
- Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.| | PubMed PubMed
- Layilin Anchors Regulatory T Cells in Skin.| | PubMed PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | PubMed PubMed
- Preventing Recurrence in Clean and Contaminated Hernias Using Biologic Versus Synthetic Mesh in Ventral Hernia Repair: The PRICE Randomized Clinical Trial.| | PubMed PubMed
- Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials.| | PubMed PubMed
- Jejunal prolapse and incarceration following feeding tube exchange.| | PubMed PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | PubMed PubMed
- Upper Gastrointestinal Endoscopy in an Academic General Surgical Program: Implications for Acute Care Surgeons.| | PubMed PubMed
- Does insurance protect individuals from catastrophic payments for surgical care? An analysis of Ghana's National Health Insurance Scheme at Korle-Bu teaching Hospital.| | PubMed PubMed
- Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.| | PubMed PubMed
- Key factors for implementing mindfulness-based burnout interventions in surgery.| | PubMed PubMed
- Integrating Robotic Technology Into Resident Training: Challenges and Recommendations From the Front Lines.| | PubMed PubMed
- Outcomes After Inguinal Hernia Repair With Mesh Performed by Medical Doctors and Surgeons in Ghana.| | PubMed PubMed
- Practice Patterns and Attitudes of Surgeons on the Use of Prophylactic Mesh to Prevent Parastola Hernia: A Cross-sectional Survey.| | PubMed PubMed
- Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial.| | PubMed PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | PubMed PubMed
- Feasibility of Formal Mindfulness-Based Stress-Resilience Training Among Surgery Interns: A Randomized Clinical Trial.| | PubMed PubMed
- Secondary peritonitis: principles of diagnosis and intervention.| | PubMed PubMed
- Evaluating the impact of the national health insurance scheme of Ghana on out of pocket expenditures: a systematic review.| | PubMed PubMed
- A Coupled Magnetoelastic Strain Sensor Array for Guiding and Monitoring Hernia Repairs.| | PubMed PubMed
- Contemporary concepts in hernia prevention: Selected proceedings from the 2017 International Symposium on Prevention of Incisional Hernias.| | PubMed PubMed
- Silver microparticles plus fibrin tissue sealant prevents incisional hernias in rats.| | PubMed PubMed
- Burnout and Stress Among US Surgery Residents: Psychological Distress and Resilience.| | PubMed PubMed
- Impact of surgical intensive care unit interdisciplinary rounds on interprofessional collaboration and quality of care: Mixed qualitative-quantitative study.| | PubMed PubMed
- Integrating coupled magnetoelastic sensors onto a flexible hernia mesh for high dynamic range strain measurements.| | PubMed PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | PubMed PubMed
- Postoperative Prophylactic Antibiotic Use following Ventral Hernia Repair with Placement of Surgical Drains Reduces the Postoperative Surgical-Site Infection Rate.| | PubMed PubMed
- Towards a full-field strain sensor for guiding hernia repairs.| | PubMed PubMed
- Appendicitis within Morgagni Hernia and simultaneous Paraesophageal Hernia.| | PubMed PubMed
- Low-dose cyclophosphamide improves survival in a murine treatment model of sepsis.| | PubMed PubMed
- A prospective, randomized controlled trial of single-incision laparoscopic vs conventional 3-port laparoscopic appendectomy for treatment of acute appendicitis.| | PubMed PubMed
- Memory regulatory T cells reside in human skin.| | PubMed PubMed
- Clinical outcomes of biologic mesh: where do we stand?| | PubMed PubMed
- Biologic mesh for ventral hernia repair: a cautionary tale.| | PubMed PubMed
- Characterizing the global burden of surgical disease: a method to estimate inguinal hernia epidemiology in Ghana.| | PubMed PubMed
- Does increased experience with laparoscopic cholecystectomy yield more complex bile duct injuries?| | PubMed PubMed
- Heparin protects against septic mortality via apoE-antagonism.| | PubMed PubMed
- NKT cells: the culprits of sepsis?| | PubMed PubMed
- NKT cells in sepsis.| | PubMed PubMed
- Chylomicrons combined with endotoxin moderate microvascular permeability.| | PubMed PubMed
- An expanding role for apolipoprotein E in sepsis and inflammation.| | PubMed PubMed
- Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease.| | PubMed PubMed
- Open incisional hernia repair at an academic tertiary care medical center.| | PubMed PubMed
- Enteric fistulas: principles of management.| | PubMed PubMed
- Anaphylaxis caused by recurrent hydatid disease.| | PubMed PubMed
- Variation in annual volume at a university hospital does not predict mortality for pancreatic resections.| | PubMed PubMed
- Predicting strangulated small bowel obstruction: an old problem revisited.| | PubMed PubMed
- Apolipoprotein E-mediated immune regulation in sepsis.| | PubMed PubMed
- The future of general surgery.| | PubMed PubMed
- Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.| | PubMed PubMed
- The value of teaching anatomy to medical students.| | PubMed PubMed
- Pancreaticoduodenectomy: volume is not associated with outcome within an academic health care system.| | PubMed PubMed
- The surgical hospitalist: a new solution for emergency surgical care?| | PubMed PubMed
- Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection.| | PubMed PubMed
- Chylomicron-bound LPS selectively inhibits the hepatocellular response to proinflammatory cytokines.| | PubMed PubMed
- The surgical hospitalist: a new model for emergency surgical care.| | PubMed PubMed
- Enhancing the mission of academic surgery by promoting scientific writing skills.| | PubMed PubMed
- Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice.| | PubMed PubMed
- Exporting excellence for Whipple resection to refine the Leapfrog Initiative.| | PubMed PubMed
- Inappropriate antibiotic use in soft tissue infections.| | PubMed PubMed
- Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model.| | PubMed PubMed
- Statins attenuate sepsis.| | PubMed PubMed
- Triglyceride-rich lipoproteins as agents of innate immunity.| | PubMed PubMed
- Apolipoprotein E: from Alzheimer's to sepsis.| | PubMed PubMed
- Image of the month--quiz case. Traumatic intramuscular cyst of the duodenum.| | PubMed PubMed
- Cholecystectomy after endoscopic sphincterotomy for common bile duct stones: is surgery necessary?| | PubMed PubMed
- Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis.| | PubMed PubMed
- Heat shock inhibits NF-kB activation in a dose- and time-dependent manner.| | PubMed PubMed
- Lipoproteins are protective beyond high-density lipoprotein cholesterol and heart disease.| | PubMed PubMed
- The evolution of endoscopy: wireless capsule cameras for the diagnosis of occult gastrointestinal bleeding and inflammatory bowel disease.| | PubMed PubMed
- Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS.| | PubMed PubMed
- An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.| | PubMed PubMed
- Induction of cytokine tolerance requires internalization of Chylomicron-Bound LPS into hepatocytes.| | PubMed PubMed
- Gallbladder ascariasis in a patient with severe pancreatitis.| | PubMed PubMed
- Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent.| | PubMed PubMed
- Lipoprotein-bound LPS induces cytokine tolerance in hepatocytes.| | PubMed PubMed
- Care of injection drug users with soft tissue infections in San Francisco, California.| | PubMed PubMed
- Chylomicron-bound endotoxin selectively inhibits NF-kappaB activation in rat hepatocytes.| | PubMed PubMed
- Hepatic endosomal trafficking of lipoprotein-bound endotoxin in rats.| | PubMed PubMed
- Endogenous lipoproteins impact the response to endotoxin in humans.| | PubMed PubMed
- Necrotizing pancreatitis during pregnancy: a rare cause and review of the literature.| | PubMed PubMed
- Extracellular matrix regulates the hepatocellular heat shock response.| | PubMed PubMed
- The lipemia of sepsis: triglyceride-rich lipoproteins as agents of innate immunity.| | PubMed PubMed
- Diet-induced protection against lipopolysaccharide includes increased hepatic NO production.| | PubMed PubMed
- Leukocytosis and free fluid are important indicators of isolated intestinal injury after blunt trauma.| | PubMed PubMed
- Obstructive jaundice alters Kupffer cell function independent of bacterial translocation.| | PubMed PubMed
- Recurrent pyogenic cholangitis.| | PubMed PubMed
- Chylomicrons alter the hepatic distribution and cellular response to endotoxin in rats.| | PubMed PubMed
- Changing management of gallstone disease during pregnancy.| | PubMed PubMed
- Surgical risk assessment and management in patients with HIV disease.| | PubMed PubMed
- Sepsis increases endocytosis of endotoxin into hepatocytes.| | PubMed PubMed
- The protective effect of serum lipoproteins against bacterial lipopolysaccharide.| | PubMed PubMed
- Chylomicrons enhance endotoxin excretion in bile.| | PubMed PubMed
- Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.| | PubMed PubMed
- Chylomicrons can inhibit endotoxin activity in vitro.| | PubMed PubMed
- Detection of endotoxin in triglyceride-rich lipoproteins in vitro.| | PubMed PubMed
- Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.| | PubMed PubMed
- Saphenous vein bypass to pedal arteries. An aggressive strategy for foot salvage.| | PubMed PubMed
- Identification of aortic thrombus by magnetic resonance imaging.| | PubMed PubMed
- Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.| | PubMed PubMed
 
    